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The Ras, Rho/Rac, and Rab families of GTPases, key modulators of cellular signaling, cytoskeletal dynamics, organelle membrane remodeling, and vesicular transport, contain various C-terminal cysteine motifs that must be isoprenylated for proper membrane localization and function [73,74]
Moreover, its neuroprotective effects are evident in cases of brain damage, stroke, and ischemia, where melatonin mitigates inflammation, reduces edema, and promotes cell survival, further emphasizing its wide-ranging therapeutic applications across various systems (Mihardja et al., 2020